James L Boyer Selected Research

Cholestasis

12/2022	Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.
12/2021	Adjunct Fenofibrate Up-regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis.
4/2021	The role of bile acids in cholestatic liver injury.
1/2021	Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis.
11/2018	Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis.
1/2017	The Role of Inflammation in the Mechanisms of Bile Acid-Induced Liver Damage.
1/2017	Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.
1/2017	Mechanisms of bile acid mediated inflammation in the liver.
12/2016	Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis.
12/2015	Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis.

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James L Boyer Research Topics

Disease

39	Cholestasis 12/2022 - 01/2002
13	Liver Diseases (Liver Disease) 12/2022 - 05/2002
13	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 12/2022 - 05/2002
10	Sclerosing Cholangitis 12/2022 - 05/2003
10	Inflammation (Inflammations) 04/2021 - 02/2011
9	Fibrosis (Cirrhosis) 01/2022 - 08/2005
6	progressive familial intrahepatic 1 Cholestasis 11/2021 - 10/2002
6	Liver Cirrhosis (Hepatic Cirrhosis) 04/2021 - 02/2011
6	Necrosis 01/2018 - 08/2005
4	Autoimmune Hepatitis 05/2022 - 08/2005
4	Neoplasms (Cancer) 01/2019 - 11/2005
3	Intrahepatic Cholestasis 11/2021 - 05/2010
3	Intrahepatic Cholestasis of Pregnancy 06/2014 - 05/2004
2	COVID-19 01/2022 - 01/2021
2	Liver Failure 12/2021 - 08/2015
2	Body Weight (Weight, Body) 01/2018 - 02/2011
2	Insulin Resistance 03/2015 - 03/2014
2	Weight Gain 03/2014 - 08/2005
2	Hemorrhage 11/2005 - 08/2005
2	Brain Diseases (Brain Disorder) 11/2005 - 08/2005
2	Ascites 11/2005 - 08/2005
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2019
1	Hematologic Neoplasms (Hematological Malignancy) 01/2019
1	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2019
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 11/2018
1	Autoimmune Diseases (Autoimmune Disease) 12/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2015
1	Non-alcoholic Fatty Liver Disease 03/2015
1	Obesity 03/2015
1	Gaucher Disease (Gaucher's Disease) 04/2014
1	Extrahepatic Cholestasis 01/2014

Drug/Important Bio-Agent (IBA)

26	Bile Acids and Salts (Bile Acids)IBA 12/2021 - 05/2002
11	CytokinesIBA 12/2022 - 08/2002
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2004
7	Pharmaceutical PreparationsIBA 06/2014 - 01/2002
6	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 12/2021 - 05/2002
5	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2018 - 08/2010
5	BilirubinIBA 01/2018 - 01/2003
4	Fenofibrate (CiL)FDA LinkGeneric 12/2022 - 03/2014
4	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 11/2021 - 10/2002
4	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 08/2015 - 08/2002
3	Fibric Acids (Fibrates)IBA 12/2022 - 05/2013
3	Multidrug Resistance-Associated ProteinsIBA 01/2014 - 04/2004
2	Hydroxyproline (4 Hydroxyproline)IBA 01/2020 - 04/2014
2	Messenger RNA (mRNA)IBA 11/2018 - 06/2006
2	Cholic AcidIBA 11/2018 - 12/2016
2	EnzymesIBA 01/2018 - 01/2014
2	Macrophage Migration-Inhibitory FactorsIBA 12/2016 - 02/2014
2	Glucose (Dextrose)FDA LinkGeneric 03/2014 - 05/2010
2	LipidsIBA 03/2014 - 05/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 09/2003
2	Adenosine Triphosphate (ATP)IBA 05/2012 - 10/2010
2	LigandsIBA 08/2005 - 05/2004
2	Carrier Proteins (Binding Protein)IBA 04/2003 - 08/2002
1	PPAR alphaIBA 12/2022
1	GlucocorticoidsIBA 01/2022
1	Tacrolimus (Prograf)FDA LinkGeneric 01/2022
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Alkaline PhosphataseIBA 12/2021
1	Semaphorins (Semaphorin)IBA 11/2021
1	Alanine (L-Alanine)FDA Link 01/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	InflammasomesIBA 01/2020
1	Immunoconjugates (Immunoconjugate)IBA 01/2019
1	AntigensIBA 01/2019
1	Inotuzumab OzogamicinIBA 01/2019
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2018
1	Organic Anion TransportersIBA 11/2018
1	Dinoprostone (PGE2)FDA Link 11/2018
1	Keratin-19 (Keratin 19)IBA 11/2018
1	Thyroxine (Levothyroxine)FDA LinkGeneric 11/2018
1	Therapeutic UsesIBA 01/2018
1	Sirtuin 1IBA 12/2016
1	ezrinIBA 12/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 12/2015
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 12/2015
1	radixinIBA 12/2015
1	sodium-hydrogen exchanger regulatory factorIBA 10/2015
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 10/2015
1	Choline (Choline Chloride)IBA 03/2015
1	2,4-Dinitrophenol (2,4 Dinitrophenol)IBA 03/2015
1	Transaminases (Aminotransferases)IBA 03/2015
1	Methionine (L-Methionine)FDA Link 03/2015
1	Glucosylceramidase (Glucocerebrosidase)IBA 04/2014
1	sphingosyl beta-glucosideIBA 04/2014
1	CollagenIBA 04/2014
1	Glucosylceramides (Glucocerebrosides)IBA 04/2014
1	SphingolipidsIBA 04/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2014
1	Glutathione (Reduced Glutathione)IBA 01/2014
1	oltiprazIBA 01/2014

Therapy/Procedure

13	Therapeutics 12/2021 - 08/2005
7	Ligation 11/2018 - 09/2003
3	Liver Transplantation 08/2015 - 08/2005
2	Drug Therapy (Chemotherapy) 12/2022 - 01/2019
2	Artificial Respiration (Mechanical Ventilation) 01/2022 - 01/2021
1	Cannula 01/2022
1	Critical Care (Surgical Intensive Care) 01/2021